《生命科学》 2015, 27(2): 161-167

HSCs辐射损伤机制研究进展

路　璐，孟爱民^*

(北京协和医学院中国医学科学院放射医学研究所天津市放射医学与分子核医学重点实验室，天津 300192)

摘　要：摘　要：HSCs (hematopoietic stem cells， HSCs) 具有自我更新和定向分化能力。电离辐射通过诱导HSCs 细胞死亡使HSCs 数量减少、诱导HSCs 衰老引起HSCs 自我更新能力的改变，以及诱导HSCs 分化异常进而损伤HSCs，深入研究HSCs 辐射损伤机制将为骨髓辐射损伤研究提供新思路。

Hematopoietic stem cells injury induced by ionizing radiation: a review of recent progress

LU Lu， MENG Ai-Min^*

(Tianjin Key Laboratory of Radiation Medicine and Molecular Nuclear Medicine， Institute of Radiation Medicine， Chinese Academy of Medical Science & Peking Union Medical College， Tianjin 300192， China)

Abstract: Abstract: Hematopoietic stem cells (HSCs) has the potentiality to renew themselves and to differentiate into different lineages of blood cells. Exposure to ionizing radiation (IR) causes HSCs damage， the mechanisms include: induction of HSCs death that leading to the reduction in HSCs reserves， induction of HSCs senescence which impairs HSCs self-renewal capacity， and promotion of HSCs differentiation that changes the banlance of hematopoietic lineages. Mechanisms whereby IR damages HSCs will provide new opportunities for developing new strategies to mitigate IR-induced bone marrow(BM) suppression.