《生命科学》 2015, 27(2): 143-150

MiR-133与恶性肿瘤关系的研究进展

郭连英^1#，高晓健^2#，刘　放²，张婷婷²，陆　霞²，张彩华¹，李墨林^1*，李传刚^3*

(¹ 大连医科大学病理生理学教研室，大连 116044；² 大连医科大学临床医学七年制2010级，大连 116044； ³ 大连医科大学附属二院泌尿外科，大连 116023)

摘　要：摘　要：微小RnA-133 (microRnA-133， miR-133) 是一种在骨骼肌和心肌特异表达的非编码小RnA，其在心肌肥大等多种肌源性疾病中发挥重要作用。近年研究发现，多种肿瘤组织存在miR-133 的表达紊乱，其通过转录后抑制靶基因，如EGFR、iGF-1R、MMPs 等的表达参与肿瘤细胞的增殖、凋亡、侵袭和转移等多种病理过程，并与肿瘤的发生发展密切相关。了解miR-133 的表达、调控及其在肿瘤等疾病中的作用及机制，可为其进一步的临床应用奠定基础。现就miR-133 与恶性肿瘤关系的研究进展进行综述。

Research progress on the relationship between miR-133 and malignant tumors

Guo Lian-Ying^1#， Gao Xiao-Jian^2#， Liu Fang²， Zhang Ting-Ting²， Lu Xia²， Zhang Cai-Hua¹， Li Mo-Lin^1*， Li Chuan-Gang^3*

(¹ 2010 Seven-year Program of Medicine， Dalian Medical University， Dalian 116044， China; ² Department of Pathophysiology， Dalian Medical University， Dalian 116044， China; ³ Division of Urology， Department of Surgery， the Second Affiliated Hospital of Dalian Medical University， Dalian 116023， China)

Abstract: Abstract: miR-133 is a group of muscle-specific non-coding small RNAs which is specifically expressed or highly enriched in skeletal muscle and/or myocardium. It plays a crucial role in muscle-related diseases such as cardiac hypertrophy. Recent studies showed that the disturbance of miR-133 expression could be detected in different kinds of tumors， and was involved in proliferation， apoptosis， invasion and metastasis of various tumor cells by directly suppressing target gene such as EGFR， IGF-1R and MMPs. It is thought that the dysregulated expression of miR-133 is closely correlated with tumorigenesis and metastasis. Understanding the expression， regulation， and the role and mechanism of miR-133 will lay a strong foundation for clinical application. The relationship between miR-133 and its target genes and malignant tumors will be summarized in this article.