《生命科学》 2015, 27(2): 120-126

肿瘤免疫组库研究促进癌症疫苗研究

张　蒙¹，王倚天¹，谢良富¹，蔡志明^1*，吴　松^1，2*

(¹ 安徽医科大学深圳市第二人民医院临床医学院，深圳 518000；² 中山大学中山医学院，广州 510000)

摘　要：摘　要：人体免疫系统是抵御病原菌侵犯、防止肿瘤发生最重要的保卫系统。针对免疫系统中T/B 淋巴细胞的免疫组库研究，找出肿瘤与TCR 或BCR 之间的关系，发现肿瘤特异性标志物，从而推动肿瘤特异性诊断、治疗及预后评估等的发展，特别是在肿瘤免疫组库研究基础上衍生出的癌症疫苗，可以在患者体内实现诱导定向肿瘤免疫反应，为肿瘤患者的治疗带来新希望。现从肿瘤免疫组库、癌症疫苗的研究进展等方面来阐述。

Tumor immune repertoire study promotes the research of tumor vaccine

ZHANG Meng¹， WANG Yi-Tian¹， XIE Liang-Fu¹， CAI Zhi-Ming^1*， WU Song^1，2*

(¹ Shenzhen Second People's Hospital， Clinical Medicine College of Anhui Medical University， Shenzhen 518000， China; ² Zhongshan School of Medicine， Sun Yat-sen University， Guangzhou 510000， China)

Abstract: Abstract: The immune system plays a vital role in the prevention of pathogen invasion and tumor development. The immune repertoire study， which targets T/B lymphocytes， can propel the development of tumor-specific diagnosis， treatment， evaluation of prognosis with the discovery of tumor-specific biomarkers after the correlation between tumor and TCR/BCR is elucidated. The tumor vaccine， derived from the tumor immune repertoire study， can induce a tumor-oriented immune response in patients， thus providing a new treatment for cancer. In this paper， we conducted a systematic review on the tumor immune repertoire study and demonstrated the advance in tumor vaccine research.