《生命科学》 2014, 26(11): 1222-1228

miR-26家族与肿瘤关系的研究进展

刘　放1，高晓健1，陆　霞1，张婷婷1，李墨林2*

(1 大连医科大学2010级七年制，大连 116044；2 大连医科大学病理生理学教研室，大连 116044)

摘　要：摘　要：miR-26 家族是由miR-26a、miR-26b、miR-1297 及miR-4465 等序列相似、结构相仿、种子区序列相同(UCAAGUA) 的微小RNA(microRNAs， miRNAs) 组成。多种组织细胞分化过程中伴有miR-26 家族表达的增加，其异常表达与特发性肺纤维化、原发性胆汁性肝硬化、多发性硬化及阿尔茨海默病等有关。近年研究报道，多种肿瘤组织亦存在miR-26 基因表达紊乱，并与肿瘤的发生发展密切相关。就miR-26 家族及其调控的靶基因与肿瘤关系的研究进展进行综述。

Progress on the relationship between miR-26 family members    and malignant tumors

LIU Fang1， GAO Xiao-Jian1， LU Xia1， ZHANG Ting-Ting1， LI Mo-Lin2*

(1 Grade 2010， Seven-year Program of Clinical Medicine， Dalian Medical University， Dalian 116044， China; 2 Department of Pathophysiology， Dalian Medical University， Dalian 116044， China)

Abstract: Abstract: miR-26 family is composed of 4 miRNAs， including miR-26a， miR-26b， miR-1297 and miR-4465， which share same seed region (UCAAGUA) and similar sequence and structure. It is known the expression of miR-26 members was increased during osteogenic differentiation， smooth muscle cell (SMC) differentiation and neurogenesis， and etc. The disturbance of miR-26 family gene expression was related with biliary cirrhosis， pulmonary fibrosis， multiple sclerosis and Alzheimer’s disease， etc. It was reported recently the disturbance of miR-26 expression existed in tumors and it might play an important role in tumorigenesis and tumor development. In this review， the progress on the relationship between miR-26 family and their target genes and malignant tumors are summarized.