《生命科学》 2014, 26(11): 1215-1221

MicroRNA介导中药活性成分抗肿瘤机制的研究进展

贵志芳，任　军，许　健*

(浙江中医药大学医学技术学院，杭州 310053)

摘　要：摘　要：MicroRNA (miRNA) 作为一类新发现的非编码RNA，其异常表达在肿瘤的病理过程中扮演着重要角色，起着类似癌基因和抑癌基因的双重作用。目前中药活性成分抗肿瘤已成为关注的热点，但其影响miRNA 的报道却较少。就近几年有关中药活性成分、miRNA 及肿瘤间关系的研究进行了综述，为今后中药活性成分抗肿瘤的机制研究提供新思路。

Progression in anti-tumor effects of active ingredients    of traditional Chinese medicine mediated by microRNA

GUI Zhi-Fang， REN Jun， XU Jian*

(Medical Technology College， Zhejiang Chinese Medical University， Hangzhou 310053， China)

Abstract: Abstract: As a new type of non-coding RNA， microRNA plays an important dual role in the progression of tumor，by functioning as a tumor suppress gene or anrogen. Currently， the active ingredients of traditional Chinese medicine already have become the popular topic of anti-tumor research， but its influence on microRNA was lessreported. This article summarized recent researches about the relationship among miRNA， tumor and active ingredients of the traditional Chinese medicine， discussed the anti-tumor mechanisms of the active ingredients of traditional Chinese medicine mediated by microRNA， which can provide a new way for the further research of theanti-tumor mechanisms of the active ingredients of traditional Chinese medicine.