《生命科学》 2014, 26(11): 1136-1142

耐辐射球菌DNA双链断裂修复机制研究新进展

赵　烨，华跃进*

(浙江大学原子核农业科学研究所，杭州 310029)

摘　要：摘　要：耐辐射球菌对于电离辐射等DNA 损伤剂具有极强的抗性，能够将同一个基因组中同时产生的高达100 个以上的DNA 双链断裂在数十小时内高效而精准地进行修复，是研究DNA 双链断裂修复机制的重要模式生物。同源重组、非同源末端连接和单链退火途径作为3 个主要的修复途径参与了耐辐射球菌基因组DNA 双链断裂的修复过程。此外，一系列新发现的重要蛋白质，如PprI、DdrB 等对于耐辐射球菌基因组的修复过程同样至关重要。根据本实验室和国内外在这一研究领域近年来的报道，以不同的修复途径为线索，综述该菌DNA 双链断裂修复机制的最新研究成果。

Research progress on DNA double-strand break repair in Deinococcus radiodurans

ZHAO Ye， HUA Yue-Jin*

(Key Laboratory of Chinese Ministry of Agriculture for Nuclear-Agricultural Sciences， Institute of Nuclear-Agricultural Sciences， Zhejiang University， Hangzhou 310029， China)

Abstract: Abstract: Deinococcus radiodurans is a popular model organism to study DNA double-strand break (DSB) repair due to its high resistance to DNA damage agents such as radiation. D. radiodurans can efficiently repair more than 100 DSBs per genome copy within dozens of hours. It has been shown that homologous recombination， non-homologous end joining and single strand annealing are three major pathways involved in the DSB repair of D.radiodurans. Additionally， a series of novel proteins were also identified， which play important roles in DSB repair. In this article， we summarized the recent progresses on DSB repair in D. radiodurans by different DNA repair pathways.