《生命科学》 2014, 26(8): 866-873

微管解聚酶驱动蛋白家族成员KIF2A研究进展

周　浩1，2，沈　涛1*

(1 云南省第一人民医院临床基础医学研究所，云南省临床分子生物学中心，云南省出生缺陷
    与遗传病重点实验室，昆明 650032；2 昆明理工大学生命科学院，昆明 650504)

摘　要：摘　要：驱动蛋白家族成员2A (KIF2A) 是一种能够与微管相互作用的蛋白，它参与了细胞内物质运输、细胞迁移、细胞形态改变，以及有丝分裂细胞纺锤体动力学等重要的细胞活动。近年来研究发现，KIF2A 凭借其独特的微管解聚能力，对神经元中神经突的生长以及细胞有丝分裂中染色体的运动起着重要的调节作用。将主要对KIF2A 在脊椎动物神经元发育和细胞有丝分裂中所行使的作用和功能进行综述。

Advance in research of microtubule depolymerase kinesin family member KIF2A

ZHOU Hao1，2， SHEN Tao1*

(1 Provincial Key Laboratory for Birth Defects and Genetic Diseases， Institute of Clinic and Basic Medical Sciences， Center of Clinical Molecular Biology， The First People’s Hospital of Yunnan Province， Kunming 650032， China; 2 College of Life Science， Kunming University of Science and Technology， Kunming 650504， China)

Abstract: Abstract: Through interactions with microtubules， the kinesin-like family member 2A (KIF2A) participates in cell activity， such as transport of various intracellular material， cell migration， cell morphological changes and mitotic spindle microtubules dynamics. Recent studies have found that KIF2A plays significant roles in neurite growth and chromosome movement during mitosis by disassembling microtubules. In this article， we reviewed its particular functions during the neuronal development and mitosis in vertebrates.