《生命科学》 2014, 26(8): 814-822

肾细胞癌基因组学研究推动靶向治疗发展

张　蒙1，杨泽雨1，谢良富1，蔡志明1*，吴　松1，2*

(1 安徽医科大学深圳市第二人民医院临床医学院，深圳 518000；2 中山大学中山医学院，广州 510080)

摘　要：摘　要：肾细胞癌( 简称肾癌) 是肾肿瘤的最主要类型，也是死亡率最高的泌尿系肿瘤之一。对于晚期肾癌患者来说，治疗方法非常局限。要想找到针对肾癌的特异性治疗方案，需要对肾癌的生物学基础有着深入的理解。旨在回顾多年来肾癌基因组学的研究进展，从组学方面分析、解释肾癌的生物学基础，找到治疗靶点，实现针对肾癌患者的特异性治疗，从而推动科学研究向临床实践的转换。

Progression of genomic research of renal cell carcinoma propels the development of targeted therapy

ZHANG Meng1， YANG Ze-Yu1， XIE Liang-Fu1， CAI Zhi-Ming1*， WU Song1，2*

(1 Clinical Medical College， Shenzhen Second People's Hospital， Anhui Medical University， Shenzhen 518000， China; 2 Zhongshan School of Medicine， Sun-Yet-Sen University， Guangzhou 510080， China)

Abstract: Abstract: Renal cell carcinoma (RCC)， which belongs to a major class of renal tumors， is one of the most fatal urological cancers. Further， few effective treatments are available to patients at an advanced stage. To find a specific treatment for RCC requires a better understanding of the biology of RCC. We performed an overview of genomics research of RCC to analyze and interprete the biology of RCC and find the therapy targets， thus propelling the conversion of scientific research to clinical practice via delivering specific treatment to RCC patients.