《生命科学》 2014, 26(8): 804-809

端粒酶逆转录酶在泌尿生殖系肿瘤中的研究进展

王倚天1，张　蒙1，王　波1，蔡志明1*，吴　松1，2*

(1 安徽医科大学深圳市第二人民医院临床医学院，深圳 518000；2 中山大学中山医学院，广州 510000)

摘　要：摘　要：端粒酶和端粒长短的变化与人类肿瘤的发生发展息息相关。其中，发生在端粒酶逆转录酶(telomerase reverse transcriptase， TERT) 启动子区域的体细胞突变对泌尿生殖系统肿瘤的发生具有重大影响。此外，TERT 的表达已被证明与肿瘤患者预后不佳相关。旨在总结TERT 在泌尿生殖系肿瘤发生发展中可能的作用以及揭示TERT 作为判断疾病预后的生物标志物和肿瘤靶向治疗新靶点的巨大潜能。

Research progress of telomerase reverse transcriptase in urogenital carcinoma

WANG Yi-Tian1， ZHANG Meng1， WANG Bo1， CAI Zhi-Ming1*， WU Song1，2*

(1 Clinical Medical College， Shenzhen Second People’s Hospital， Anhui Medical University， Shenzhen 518000， China; 2 Zhongshan School of Medicine， Sun Yat-sen University， Guangzhou 510000， China)

Abstract: Abstract: Telomerase and the control of telomere length are closely related to the development of human cancer. Mutations in the promoter region of telomerase reverse transcriptase (TERT) will have an enormous impact on the tumourigenesis process of urogenital tumour. In addition， the expression of TERT has also been proved to have correlations with poor prognosis. This article summarizes the current potential roles of TERT in the tumorigenesis and development of urogenital carcinoma， suggests that TERT holds promise as a biomarker for the evaluation of prognosis， and has great potential as the basis for targeted therapies.