《生命科学》 2014, 26(8): 790-798

肺癌干细胞生物学特性研究进展

安世民1，2，丁旭苹1，朱　亮1，2*

(1 上海交通大学医学院药理学教研室，上海 200025；2 上海交通大学医学院转化医学协同创新中心，上海 200025)

摘　要：摘　要：肺癌是具有高度侵袭性的一类恶性肿瘤，传统以手术结合放化疗的治疗手段对肺癌的治疗效果不佳，5 年生存率仅为20%~30%，其中重要原因之一是肺癌容易转移与复发。在与肺癌长期斗争的过程中，人们发现肺癌组织中存在一小群肺癌干细胞(lung cancer stem cells， LCSCs)，它们是肺癌难以治愈和复发的根本原因。从LCSCs 的发现、相关的生物学特性和信号转导通路，以及LCSCs 与表皮- 间质转化(epithelialmesenchymal transition， EMT) 之间的关系等方面对LSCSs 进行综述。

Research advancement on biological characteristics of lung cancer stem cells

AN Shi-Min1，2， DING Xu-Ping1， ZHU Liang1，2*

(1 Department of Pharmacology and Chemical Biology， School of Medicine， Shanghai Jiao Tong University， Shanghai 200025， China; 2 Collaborative Innovation Center for Translational Medicine， School of Medicine， Shanghai Jiao Tong University， Shanghai 200025， China)

Abstract: Abstract: Lung cancer is a highly invasive type of cancer. Therapy effect of traditional treatment with surgery in combination with chemoradiotherapy is not satisfying. Since lung cancer is easy to be metastasis and its recurrence rate is high， the overall 5-year survival rate is only about 20%~30%. Struggling with lung cancer for a long time， people realized the existence of lung cancer stem cells in lung cancer tissue， which is the major reason why lung cancer is difficult to be cured and has high recurrence rate. The present review addresses aspects including the finding of lung cancer stem cells， their relevant biological characteristics， signaling pathways and relationship with epithelial-mesenchymal transition.