《生命科学》 2014, 26(7): 756-761

miR-92a家族与肿瘤关系的研究进展

李墨林¹，关兴芳²，孙宇强³，李传刚⁴，王 雪⁵，舒晓宏^5*

(1 大连医科大学病理生理学教研室，大连 116044；2 大连医科大学2010级医疗系，大连 116044；3 大连医科大学2009级七年制，大连 116044；4 大连医科大学附属二院泌尿外科，大连 116023；5 大连医科大学药学院，大连 116044)

摘　要：摘　要： miR-92a 家族基因是由miR-25、miR-92a~1、miR-92a~2 和miR-363 等序列相似、结构相仿、种子区序列相同的微小RNA (microRNAs) 组成，它们分别来自在进化过程中高度保守并互为旁系同源序列的miR-106b~25、miR-17~92 和miR-106a~363 基因簇。目前研究认为，miR-92a 家族基因是一组与血管内皮细胞形成有关的miRNAs，其表达紊乱与肿瘤的发生发展密切相关。就miR-92a 家族基因及其靶基因与肿瘤关系的研究进展进行综述。

Progress of miR-92a family in tumorigenesis

LI Mo-Lin¹， GUAN Xing-Fang²， SUN Yu-Qiang³， LI Chuan-Gang⁴， Wang Xue⁵， SHU Xiao-Hong^5*

(1 Department of Pathophysiology， Dalian Medical University， Dalian 116044， China; 2 Grade 2010， Clinical Medicine， Dalian Medical University， Dalian 116044， China; 3 Grade 2009， Seven-year Program of Clinical Medicine， Dalian Medical University， Dalian 116044， China; 4 Division of Urology， Department of Surgery， the Second Affiliated Hospital of Dalian Medical University， Dalian 116027， China; 5 College of Pharmacy， Dalian Medical University， Dalian 116044， China)

Abstract: Abstract: miR-92a family is composed of 4 miRNAs in cluding miR-25， miR-92a~1， miR-92a~2 and miR-363， which share same seed region and similar sequence and structure. They arise from three different paralog clusters miR-17~92， miR-106a~363， and miR-106b~25 that are highly conserved in the process of evolution. It was thought that miR-92a family was a group of miRNA correlated with formation of endothelial cells. It was demonstrated that the disturbance of the expression of miR-92a family was related with tumorigenesis and tumor development. In this review， the progress of the relationship between miR-92a family and their target genes and malignant tumors is summarized.