《生命科学》 2014, 26(7): 751-755

miR-155在常见病原微生物感染中的研究进展

曾芙蓉，陈　偲，汤立军^*

(中南大学生命科学学院分子生物学系，长沙 410078)

摘　要：摘　要： microRNAs (miRNAs) 是一类长度为17~25 nt，进化上保守的非编码单链小RNA，成熟的miRNAs通过碱基互补配对的方式识别靶mRNA，并根据互补程度介导沉默复合体降解靶mRNA 或者阻遏靶mRNA的翻译。miR-155 是miRNAs 家族中的典型代表，其不仅参与调控肿瘤细胞的增殖、分化和凋亡，而且在微生物感染过程及免疫炎症反应中也发挥着重要作用。将对miR-155 在常见的几种病原微生物感染过程中发挥的作用做系统综述。

The research progress of miRNA-155 in the process of pathogenic microorganism infection

ZENG Fu-Rong， CHEN Cai， TANG Li-Jun^*

(Department of Molecular Biology， School of Life Science， Central South University， Changsha 410078， China)

Abstract: Abstract: microRNAs (miRNAs) are a class of evolutionarily conserved， single-stranded， non-coding RNA molecules consisting of 17~25 nt. Mature miRNAs can recognize the target mRNA through base pairing. They degrade target mRNA or suppress gene translation according to the complementary extents. MiR-155 is a typical representative of miRNA family. It can not only regulate cell proliferation， differentiation and apoptosis， but also play an important role in various microbial infection， immune and inflammation response. This review will highlight the function of miR-155 in the process of infection with several pathogenic microorganisms