《生命科学》 2014, 26(7): 717-724

Stat3的功能多样性

季巾君¹，潘洁莉²，谢冠群²，徐　莉^1*

(1 浙江中医药大学分析测试中心，杭州 310053；2 浙江中医药大学基础医学院， 杭州 310053)

摘　要：摘　要：Stat3 为信号转导与转录激活因子(signal transducers and activators of transcription， STAT) 蛋白家族的成员，在维持胚胎干细胞的全能性及调节免疫中发挥重要作用。Stat3 基因敲除的小鼠可引起胚胎致死，其异常表达与多种疾病密切相关。精确的认识Stat3 在不同组织和细胞中的功能有助于我们了解Stat3 在疾病发生中的作用。汇总了近年来对Stat3 不同位点氨基酸的功能和修饰研究，以及不同组织中Stat3 条件型敲除小鼠中的研究进展，并从这两个方面阐明Stat3 的功能多样性。

Functional diversity of Stat3

JI Jin-Jun¹， PAN Jie-Li²， XIE Guan-Qun²， XU Li^1*

(1 Center of Forecasting and Analysis， Zhejiang Chinese Medical University， Hangzhou 310053， China; 2 College of Basic Medicine， Zhejiang Chinese Medical University， Hangzhou 310053， China)

Abstract: Abstract: Stat3 is a member of the Stat protein family， it plays an important role in maintaining the pluripotency of embryonic stem cells and regulation of the immune responses. Unlike all other members of the Stat gene family， ablation of Stat3 leads to embryonic lethality. Abnormal expression of Stat3 was founded in a variety of diseases. Accurate understanding of the functions of Stat3 in different tissues and cells can help us find Stat3’s function in process of disease. This review mainly describes modification of different amino acids sites of Stat3 and the research work of Stat3 conditional knockout mice in different tissues， then clarify the functional diversity of Stat3 from these two aspects.