《生命科学》 2014, 26(6): 657-664

多发性硬化和视神经脊髓炎的体液免疫机制及其干预策略

徐　雁，崔丽英^*

(中国医学科学院北京协和医院神经科，北京100730)

摘　要：多发性硬化 (multiple sclerosis， MS) 和视神经脊髓炎(neuromyeltis optica， NMO) 是两个独立的中枢神经系统炎性脱髓鞘疾病，B 细胞和体液免疫在二者发生发展中发挥了重要作用。越来越多证据显示，针对B 细胞和/ 或抗体的治疗有可能同时对抗MS 和NMO。就B 细胞及其体液免疫在MS 和NMO 发生发展及治疗中的作用做一综述。

The role of humoral autoimmunity in multiple sclerosis and neuromyelitis optica and therapeutic strategy

XU Yan， CUI Li-Ying^*

(Department of Neurology， Peking Union Medical College Hospital， Beijing 100730， China)

Abstract: Multiple sclerosis (MS) and neuromyelitis optica (NMO) are two different inflammatory demyelinating diseases in central nervous system. B cells and humoral immune responses play an important role in the immunopathogenesis of MS and NMO. There is growing evidence that treatments specifically targeting B cells and/or antibodies are effective in both MS and NMO. This review therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO.