《生命科学》 2014, 26(6): 560-570
摘 要：帕金森病(Parkinson’s disease， PD) 是一种多发于中老年期的，以黑质多巴胺能神经元选择性变性为主要病理改变的神经系统退行性疾病。目前，对该病的病因和发病机制还不清楚，尚未建立特异的、灵敏的预警和早期诊断体系以及确切有效的神经保护和治疗的方法。PD 的发病与人口老龄化密切相关，随着我国老龄化社会的到来，PD 发病率不断增加，给社会和经济都带来严重的危害，因此，越来越受到国家和政府的关注。本世纪以来，科技部先后设立“神经变性病的机制和防治的基础研究”以及“帕金森病发病机制及防治策略的研究”两个973 计划项目，以求系统、深入研究PD 的病因，神经元选择性、进行性变性死亡的关键机制以及寻找能延缓或阻断疾病的药物等防治新策略，期望推动我国的PD 研究，为建立PD防治的新理论、新策略和新技术等奠定扎实的基础。对这两个973 项目PD 研究团队的主要原创性工作进行综述。
Abstract: Parkinson’s disease (PD) is a progressive neurodegenerative disorder， characterized by degeneration of dopamine-containing neurons located in substantia nigra. Up to now， the specific etiology and pathogenesis of PD are unknown. There has not yet a specific， sensitive predictive and early diagnostic system， and treatment is basically symptomatic. The incidence of PD is rising with the increase of aging population， and bringing great challenge to society and economy. So our country and government pay more and more attention to PD research. The Ministry of Science and Technology of China has approved two 973 projects， the Research of Pathogenesis and Treatment Strategy on Neurodegenerative Disease and the Research of Pathogenesis and Treatment Strategies on PD. The review mainly focuses on the etiology， pathogenesis， early diagnostic system and treatment strategies of PD. All the results will contribute to the progress of our country’s PD research.
