《生命科学》 2014, 26(4): 419-422

PD-1/PD-L1在脓毒症发生发展过程中的作用研究

周园红¹，沈雪莲¹，刘朝奇²，刘　强^1*

(1 三峡大学第一临床医学院/宜昌中心人民医院，宜昌 443003；2 三峡大学分子生物学研究所，宜昌 443002)

摘　要：脓毒症是机体应对感染而发生的一种全身性炎性反应，且发病机制复杂，免疫调节紊乱是最显著的特点之一。程序性死亡分子-1 (programmed death-1， PD-1) 及其配体(programmed death ligand-1， PD-L1)是介导机体免疫反应的负性调节信号，在脓毒症的发生发展过程中扮演着重要角色。因此，对PD-1/PD-L1在脓毒症的发生发展及治疗中所发挥的作用进行简短归纳。

PD-1/PD-L1: the effect on the occurrence and development of sepsis

ZHOU Yuan-Hong¹， SHEN Xue-Lian¹， LIU Chao-Qi²， LIU Qiang^1*

(1 First College of Clinical Medical Science， China Three Gorges University/Yichang Central People’s Hospital， Yichang 443003， China; 2 Institute of Molecular Biology， Three Gorges University， Yichang 443003， China)

Abstract: Sepsis is the systemic inflammatory reaction responding to the infection， however， the underlying mechanisms have not been fully understood. Immune disorder is one of the most remarkable characteristics for sepsis. Programmed death-1 (PD-1) and its ligand (PD-L1) are the negative-regulated signals mediating immune response， which play an important role in the occurrence and development of sepsis. In this review， we will make a brief summary about the effect of PD-1/PD-L1 on the occurrence， development and treatment of sepsis.