《生命科学》 2014, 26(1): 9-14

β淀粉样肽在阿尔兹海默病中作用的逐步认识

黄福德

(中国科学院上海高等研究院干细胞与纳米医学中心系统生物学实验室，上海 201210)

摘　要：摘　要： 阿尔兹海默病(Alzheimer’s disease， AD) 是老年痴呆症中最常见的一种疾病，其特征性病理变化之一是大脑内淀粉样斑块积累。自从淀粉样斑块的主要成分被发现是β 淀粉样肽(Aβ) 后，大量研究表明，Aβ 积累在AD 的大脑病理变化和认知障碍中起重要作用。在AD 大脑中，Aβ 以可溶和不可溶的聚合形式在细胞内外积累。介绍了Aβ 积累在AD 中起重要作用的依据，人们对于不同聚合形式的Aβ 和细胞内外积累的Aβ 在AD 中的作用的认识过程和存在的问题。
    

The gradual understanding of the role of β amyloid in Alzheimer’s disease

Huang Fu-De

(Laboratory of System Biology， Center for Stem Cell and Nanomedicine， Shanghai Advanced Research Institute， Chinese Academy of Sciences， Shanghai 201210， China)

Abstract: Abstract: Alzheimer’s disease (AD) is the most common cause of dementia in the elderly people. Since the discovery that β amyloid (Aβ) was found to be the primary component of amyloid plaques in the AD brain， enormous data exist to support that Aβ plays an important role in the pathological alteration and cognitive impairment of AD. Aβ exits as soluble and insoluble assemblies， and accumulates both intracellularly and extracellularly in the AD brain. This review summarized the major evidence supporting the important role of Aβ in AD， and the gradual understanding that the role of Aβ in AD pathogenesis depends on its assembly state and accumulation location.