《生命科学》 2013, 25(12): 1153-1160

补体系统及其在肝损伤再生中的作用

王　颖^1，2，叶波平¹，华子春^2*

(1 中国药科大学生命科学与技术学院，南京 210009；2 南京大学医药生物技术国家重点实验室，南京 210093)

摘　要：摘　要：补体系统是机体免疫防御机制的重要组成部分，参与免疫识别和防御。近年来，系统研究发现补体除免疫调节外，还具有参与生殖发育、成骨、组织和器官再生等重要生理机能的作用。多项研究报道了补体活化和各种肝损伤/ 再生的关系，对此进行综述，以期促进对补体多样性功能的了解。

Complement and liver regeneration        

WANG Ying1，2， YE Bo-Ping1， HUA Zi-Chun2*

(1 School of Life Science and Technology， China Pharmaceutical University， Nanjing 210009， China;
    2 The State Key Laboratory of Pharmaceutical Biotechnology， Nanjing University， Nanjing 210093， China)

Abstract: Abstract: Complement system is known as highly sophisticated immune defense mechanism and effector arm in host defense against serial infectious agents， such as cellular debris， apoptotic cells and foreign intruders. For recent decades， the traditional perception of complement in immunity has been drastically challenged by accumulating evidence for novel and unexpected functions. Generally， complement is now known to be involved in metabolism， reproduction， osteogenesis， tissue regeneration and stem cell biology， etc. In this review， recent discoveries are referred to discuss the previously under-appreciated role of complement in liver regeneration induced by various pathogens. The unintegrated effect of complement on regeneration priming and pro-inflammation modulates the balance between liver regeneration and injury， which determines the pathological process.