《生命科学》 2013, 25(11): 1121-1125

环境雌激素的生殖毒性的分子机理研究进展

侯　苹^1，2，张娴文¹，白　洁^1*

(1 昆明理工大学医学院，昆明 650500；2 昆明医科大学第一附属医院妇科，昆明 650106)

摘　要：摘　要：环境激素(environmental endocrines， EEs) 是外源性激素，可模拟体内天然激素与机体内的受体以及相应靶点结合，导致内分泌系统以及生殖系统功能紊乱。环境激素所产生的效应十分复杂，因此，进一步明确其毒性机理将为环境激素所致危害的预防和治疗提供理论依据。就环境雌激素的生殖、发育等毒性机理作一综述。

Progress in molecular mechanisms on reproductive toxicity of environmental estrogens        

HOU Ping^1，2， ZHANG Xian-Wen¹， BAI Jie^1*

(1 Medical Faculty， Kunming University of Science and Technology， Kunming 650500， China; 2 Gynaecological Department， the First Affiliated Hospital of Kunming Medical University， Kunming 650106， China)

Abstract: Abstract: Environmental endocrines (EEs) are environmental hormones which bind receptors and the targets by imitating natural hormones and result in endocrine system and reproductive system disorders. The effects of EEs are very complex. Thus， further studies on its molecular mechanisms will provide theoretic basis for the treatment and prevention of toxicity of EEs. This paper reviewed the toxicity mechanisms of environmental estrogens on reproduction and development.