《生命科学》 2013, 25(11): 1100-1104

前列腺凋亡反应蛋白-4抗肿瘤作用研究进展

张娴文，白　洁^*

(昆明理工大学医学院，昆明 650500)

摘　要：摘　要：前列腺凋亡反应基因-4 (prostate apoptosis response gene-4， par-4) 是从凋亡的前列腺癌细胞中分离出来的一种基因，该基因编码的产物是前列腺凋亡反应蛋白4 (Par-4)。Par-4 可通过细胞内、外途径调节各种分子表达，诱导癌细胞凋亡，选择性抑制肿瘤细胞生长，因此，Par-4 的表达与肿瘤的发生、发展及预后有密切的联系。Par-4 在治疗恶性肿瘤中表现出良好的肿瘤细胞靶向杀伤效应，对正常组织细胞无明显影响，故具有极其重要的应用价值。就Par-4 特异性诱导肿瘤细胞凋亡及其潜在抗肿瘤作用的进展进行综述。

Study progress in the antitumor effects of Par-4

ZHANG Xian-Wen， BAI Jie^*

(Medical Faculty， Kunming University of Science and Technology， Kunming 650500， China)

Abstract: Abstract: Prostate apoptosis response gene-4 (par-4) was first identified from apoptotic prostate cancer cells. Prostate apoptosis response protein-4 (Par-4) can induce tumor cell apoptosis and selectively inhibit tumor cell growth through intracellular and extracellular pathways. Thus， Par-4 is involved in the occurrence， development and prognosis of tumors. Furthermore， Par-4 exhibits excellent malignant tumor cell killing effects without influencing normal cells and tissues. This paper reviews the progress of Par-4 specially inducing tumor cell apoptosis and its potential roles in anti-tumors.