《生命科学》 2013, 25(11): 1089-1093
摘 要：摘 要：支气管哮喘( 简称哮喘) 是一种以Thl/Th2 免疫失衡、Th2 优势应答为特征的慢性气道炎症性疾病。SOCS-3 是一类与细胞因子JAK/STAT 信号转导途径有关的负反馈调节因子，参与细胞固有免疫、获得性免疫和炎症反应。近年来研究发现，在哮喘的发生发展中SOCS-3 均表现出分子水平或功能的异常，提示SOCS-3 可作为哮喘诊断和治疗的新靶点。就SOCS-3 与哮喘的关系研究进展进行综述，讨论其在哮喘Th1/Th2 免疫失衡中的作用。
Abstract: Abstract: Bronchial asthma (asthma) is a kind of chronic airway inflammatory diseases， characterized by immune imbalance of Thl/Th2 cytokine and Th2-skewed immune response. SOCS-3 is a negative feedback regulatory protein related to the cytokine signaling transduction pathways of JAK/STAT， which is mainly involved in innate and adaptive immunity and inflammation. In recent years， researches have found that SOCS-3 has an abnormal molecular level or impaired function during the onset and development of asthma. Therefore， SOCS- 3 may serve as a therapeutic and diagnostic target for asthma. In this review， the advances of research on relationship between SOCS-3 and asthma were summarized， and the roles of SOCS-3 in the imbalance of Th1 and Th2 in asthma were discussed.
