《生命科学》 2013, 25(11): 1084-1088

结核分枝杆菌对宿主巨噬细胞死亡方式的调控

杨瑞丽^1*，孙佳楠¹，陆　伟²

(1 东南大学病原生物学与免疫学系，南京 210009；2 江苏省疾病预防控制中心，南京 210009)

摘　要：摘　要：结核分枝杆菌(Mycobacterium tuberculosis， Mtb) 感染后能抑制宿主巨噬细胞(MФ) 的免疫反应，并在其中生存、复制。研究表明Mtb 减毒株感染主要诱导宿主MФ 凋亡，凋亡能抑制胞内Mtb 的活力；而Mtb 毒力株感染能抑制凋亡的完成，诱导MФ 坏死，最终导致Mtb 扩散、感染临近细胞。通过对Mtb 感染诱导宿主MФ 不同死亡方式的讨论，进一步认识Mtb 的致病机制。

The death of host macrophages regulated by Mycobacterium tuberculosis

YANG Rui-Li^1*， SUN Jia-Nan¹， LU Wei²

(1 Department of Pathogenic Biology and Immunology， School of Medicine，
    Southeast University， Nanjing 210009， China; 2 Department of Chronic Infectious Diseases， Jiangsu Provincial Center for Disease Prevention and Control， Nanjing 210009， China)

Abstract: Abstract: Mycobacterium tuberculosis (Mtb) can suppress host macrophage (MФ) immune defenses， and use host MФ resources for survival and replication. Attenuated strains of Mycobacteria induce more apoptosis than their virulent counterparts Mtb， which diminish pathogen viability. However， virulent Mtb strains inhibit the completion of apoptosis and foil host defenses， which results in necrosis of macrophages， and then the exit of bacteria from the macrophage and spread. This paper intends to further introduce the pathogenesis of Mtb through the discussion of the different death modalities of host MФ infected with Mtb.