《生命科学》 2013, 25(11): 1071-1076

炎性因子与阿尔茨海默病

侯宛祺¹，戴雪伶^2，3，姜招峰^2，3*

(1 首都师范大学生命科学学院，北京 100048；2 北京联合大学生物活性物质与功能食品北京市重点实验室，北京 100191；3 北京联合大学功能食品科学技术研究院，北京 100191)

摘　要：摘　要：阿尔茨海默病(Alzheimer’s disease， AD) 是一种中老年人易患的中枢神经系统退行性疾病，其主要临床表现为不可逆性、进行性的记忆力衰退，目前发病机制不清。AD 患者脑内存在异常高水平的炎性因子及其受体、补体、调节蛋白以及化学因子等免疫炎性的标志物，提示炎性因子可能与AD 的发病过程密切相关。综述了近年来有关炎性因子与AD 发生发展关系的研究进展。

Inflammatory cytokines and Alzheimer's disease    

HOU Wan-Qi¹， DAI Xue-Ling^2，3， JIANG Zhao-Feng^2，3*

(1 College of Life Sciences， Capital Normal University， Beijing 100037， China; 2 Beijing Key Laboratory of Bioactive Substances and Functional Foods， Beijing Union University， Beijing 100191， China; 3 Functional Food Research Institute of Science and Technology， Beijing Union University， Beijing 100191， China)

Abstract: Abstract: Alzheimer's disease (AD) is a neurodegenerative disorder of the central nervous system and predominantly occurs in the elderly， but so far the pathogenesis is still unknown mostly. Previous studies indicate that abnormally high levels of inflammatory cytokines and their receptors， complements and regulatory proteins as well as immune inflammatory markers have been observed in AD brains， suggesting a potential correlation between inflammatory cytokines and AD. Herein in this paper we reviewed the correlation between inflammatory cytokines and the occurrence and development of AD.