《生命科学》 2013, 25(10): 1027-1035

五羟色胺和多巴胺与攻击行为的关联研究进展

段云峰，吴晓丽，王　涛，金　锋^*

(中国科学院心理研究所心理健康重点实验室行为生物学室，北京100101)

摘　要：摘　要：五羟色胺(5-HT) 和多巴胺(DA) 是影响攻击行为的重要神经递质。参与这两种神经递质合成和分解、运输及信号转导等过程的物质均可能影响攻击行为，如影响5-HT 作用的色氨酸、色氨酸羟化酶、单胺氧化酶、5- 羟吲哚乙酸及5-HT 转运体和5-HT 受体；影响DA 作用的多巴胺β 羟化酶和儿茶酚胺邻位甲基转移酶以及DA 转运体。未来攻击行为研究，应考虑色氨酸自身代谢、受体亚型及其他单胺类和儿茶酚胺类神经递质的影响。将肠道微生物纳入攻击行为研究也是未来研究的新方向。

Research progress on the correlations of aggressive behavior with serotonin and dopamine    

DUAN Yun-Feng， WU Xiao-Li， WANG Tao， JIN Feng^*
    

(Behavioral Biology Laboratory， Key Laboratory of Mental Health， Institute of Psychology， Chinese Academy of Sciences， Beijing 100101， China)

Abstract: Abstract: Serotonin (5-HT) and dopamine (DA) are important neurotransmitters that affect aggressive behavior. The substances involved in their syntheses， degradation， transport and signal transduction processes may also affect aggressive behavior， such as tryptophan， tryptophan hydroxylase (TPH)， monoamine oxidase (MAO)， 5-hydroxyindole acetic acid (5-HIAA)， 5-HT transporter (5-HTT) and 5-HT receptors that have an influence on the function of 5-HT. Similarly， dopamine β-hydroxylase (DBH)， catechol-O-methyltransferase (COMT) and DA transporter (DAT) can affect the function of DA. In the future， tryptophan metabolism， receptor subtypes and other monoamine or catecholamine neurotransmitters should be considered in aggression study. Furthermore， taking the gut microbes into the aggressive behavior study shows a new direction for future research.