《生命科学》 2013, 25(10): 1022-1026

血清白蛋白的生物学特性研究进展

李　荣，胡维新^*

(中南大学生物科学与技术学院分子生物学研究中心，长沙 410078)

摘　要：摘　要：人类血清白蛋白是单链、多结构域的大分子物质，是血浆中含量最丰富，也是人体中很重要的一种蛋白质。白蛋白有77 个结合配体的位点，能与一系列内源性和外源性物质相结合，起着存储和转运的作用。此外，白蛋白还具有维持血液正常的渗透压、抗氧化及参与炎症反应等一系列的生理和药理学功能在临床上，白蛋白的应用已有50 多年的历史，主要应用于中风、烧伤、低白蛋白血症等。回顾了近年来相关文献，就白蛋白的生物学特性作一阐述。

Molecular and biological characteristics of human serum albumin

LI Rong， HU Wei-Xin^*

(Molecular Biology Research Center， School of Biological Science and Technology，
    Central South University， Changsha 410078， China)

Abstract: Abstract: Human serum albumin (HSA)， a monomeric multidomain macromolecule and the most abundant protein in plasma， is an important protein in the human body. HSA displays extraordinary ligand binding properties and acts as a depot and carrier for many endogenous and exogenous compounds. Albumin is known to have quite diverse functions including oncotic pressure regulation， antioxidation， etc. Moreover， HSA is widely used clinically to treat several diseases， such as shock， burns and hypoalbuminemia. Here， the molecular and biological characteristics of HSA are reviewed， which will contribute to understanding of the key role of HSA.