《生命科学》 2013, 25(9): 891-896

L-肌肽影响血糖、血压、脂质代谢的相关研究进展

陶燕来¹，吴　涛¹，徐　亮¹，富浩轩¹，江倩茹¹，钮亭亭²，傅正伟^1*

(1 浙江工业大学生物与环境工程学院生理调控实验室，杭州 310014；2 上海体育学院，上海 200438)

摘　要：摘　要： L- 肌肽(β- 丙氨酸-L- 组氨酸) 在哺乳动物骨骼肌中合成。L- 肌肽可影响自主神经系统相关的生理功能，通过影响所支配器官和组织的交感及副交感神经活性引起血压、血糖、食欲、脂质分解和产热等生理功能的变化。然而，由L- 肌肽引发的生理功能的变化又能因组胺H1、 H3 受体拮抗剂或生物钟主钟视交叉上核(SCN) 双侧损伤而解除。因此，主要概述在生物钟和组胺能神经的参与下，L- 肌肽通过自主神经途径调节血糖、血压、脂质分解和产热等生理机能的相关研究进展。
    关键词：L- 肌肽；交感神经；副交感神经；生物钟；组胺能神经

Advances on effects of L-carnosine on blood glucose， blood pressure    and lipid metabolism

TAO Yan-Lai¹， WU Tao¹， XU Liang¹， FU Hao-Xuan¹， JIANG Qian-Ru¹， NIU Ting-Ting²， FU Zheng-Wei^1*

(1 College of Biological and Environmental Engineering， Zhejiang University of Technology， Hangzhou 310014， China; 2 Shanghai University of Sport， Shanghai 200438， China)
    

Abstract: Abstract: L-carnosine (β-alanyl-L-histidine) is synthesized in mammalian skeletal muscle. It is reported that L-carnosine affects physiological functions through the autonomic nerves system. In particular， L-carnosine affects the activity of sympathetic and parasympathetic nerves to further induce changes in blood pressure， blood glucose， appetite， lipolysis and thermogenesis. The changes in physiological functions mediated by L-carnosine are eliminated by histamine H1 or H3 receptor antagonists and bilateral lesions of the hypothalamic suprachiasmatic nucleus (SCN)， a master circadian clock. This article briefly reviews the advances on the effects of L-carnosine on physiological functions such as blood glucose， blood pressure， lipolysis， and thermogenesis via autonomic nerves system and with the involvement of the circadian clock and histaminergic neurons.
    Key words: L-carnosine; sympathetic nerve; parasympathetic nerve; circadian clock; histaminergic neurons