《生命科学》 2010, 22(8): 755-760

抗凝血蛋白的抗凝溶栓机制

顾　峰，胡宗利*，陈国平，胡功铃，解巧利

(重庆大学生物工程学院，重庆 400030)

摘　要：摘　要：自然界中存在着大量具有抗凝溶栓活性的生物大分子，如水蛭素、蚓激酶等。这些生物大分子主要是通过抑制凝血酶及凝血因子活性，水解纤维蛋白或纤溶酶原，或是抑制血小板聚集来达到抗凝溶栓的作用。该文对这些活性物质的抗凝溶栓机制进行综述。
    关键词：凝血机制；抗凝血蛋白；抗凝溶栓机制

Anticoagulant protein: anticoagulant and thrombolysis mechanism

GU Feng， HU Zong-li*， CHEN Guo-ping， HU Gong-ling， XIE Qiao-li

(College of Bioengineering， Chongqing University， Chongqing 400030， China)

Abstract: Abstract: Many bioactive substances were obtained from natural sources， such as Hirudin and Lumbrokinase. These bioactive substances have anti-thrombin activities， anti-platelet aggregative activities and fibrinolytic activities. This paper reviews the anticoagulant and thrombolysis mechanism of these anticoagulant proteins.
    Key words: blood clotting mechanism; anticoagulant protein; anticoagulant and thrombolysis mechanism