《生命科学》 2013, 25(8): 823-828

ERα介导的基因转录在子宫内膜癌变中的研究进展

高振家¹，赵　越^2*

(1 中国医科大学七年制，沈阳 110001；2 中国医科大学基础医学院，卫生部细胞生物学重点实验室，教育部医学细胞生物学重点实验室，染色质生物学研究室，沈阳 110001)

摘　要：摘　要： 雌激素受体α (estrogen receptor α， ERα) 是核受体超家族成员，主要以配体依赖的方式发挥其生物学功能。ERα 对女性生殖系统发育起作用，影响子宫内膜的增殖与分化。研究证实，ERα 介导的基因转录在I 型子宫内膜癌变进程中扮演着重要的角色。此外，雌激素受体β (estrogen receptor β， ERβ) 或雌激素相关受体(estrogen-related receptor， ERR) 也参与此过程中，并与ERα 有功能联系。主要综述ERα 介导的基因转录中参与转录调控的辅助调节因子、ERα 下游重要的靶基因及其在子宫内膜癌中的重要作用，为子宫内膜癌的早期发现和治疗提供新的思路和靶点。

Estrogen receptor α-mediated transactivation in endometrial cancer

GAO Zhen-Jia¹， ZHAO Yue^2*

(1 Seven-year Postgraduate， China Medical University， Shenyang 110001， China; 2 Laboratory of Chromatin Biology， Department of Cell Biology， Key Laboratory of Public Health Ministry of China， Department of Medical Cell Biology of Ministry of Education， China Medical University， Shenyang 110001， China)

Abstract: Abstract: The estrogen receptor α (ERα) is a member of the nuclear receptor superfamily. ERα exerts its biological function via regulating transcription of its target genes in a ligand-dependent manner. ERα is important for the development of reproductive system in female and influences cell proliferation and differentiation of endometrium. ERα-mediated transcription plays a critical role in the progression of endometrial carcinoma. Meanwhile，the estrogen receptor β (ERβ) or estrogen-related receptor (ERR) is also involved in this process， and has the functional association with ERα. Based on the updated publications， we reviewed here some co-regulators involved in the modulation of ERα-mediated transactivation， several accepted ERα target genes， and their important roles in endometrial cancer. It would provide novel ideas and targets for early detection and treatment of endometrial carcinomas.