《生命科学》 2013, 25(8): 812-821
摘 要：摘 要：血管异常与畸形是多种疾病( 如血管栓塞、肿瘤、动脉瘤畸形等) 的常见形态改变，会引发其他一系列更加严重的生理病变。因此，多年以来，大量的研究者都希望通过分析血管的分布和形态变化，实现对这些疾病的预防、发现和诊断。近年来，随着成像手段和图像处理技术的突飞猛进，借助血管数字减影技术(digital subtraction angiography， DSA)、磁共振血管造影技术(magnetic resonance angiography， MRA)、Micro-CT 等多种多样的成像手段以及同步辐射这种全新的光源，可获得的血管图像的分辨率有了大幅提高，针对血管网络的定量分析有了显著的发展。总结了一般血管定量分析的流程，回顾了近年来在普通Micro-CT、同步辐射等新兴领域血管定量分析工作取得的最新进展，讨论了未来定量分析工作的发展趋势和应用前景。
Abstract: Abstract: Vessel abnormality and malformation are common in many serious diseases， such as cancer， thrombosis and meridians varicose， which finally lead to vascular lesions and malfunction. Therefore， over the years， researchers have been trying to prevent， detect and diagnose these diseases by analyzing the distributional and morphological changes of the blood vessels. Thanks to the development of high-resolution imaging technology such as DSA， MRA， Micro-CT and synchrotron radiation imaging， we can obtain lots of high resolution images， which can be used in further vascular quantification. This paper summarized the general process of vascular quantification， reviewed the progress made in recent years in the field of vascular quantification based on high-resolution imaging， and discussed the development trends and application for future quantitative analysis.
