《生命科学》 2013, 25(7): 694-699
摘 要：摘 要：核受体是一类在生物体内分布广泛、成员众多的转录因子，参与体内亲脂激素、维生素、脂质和其他细胞内信号的转录过程。核受体与相应的配体及其辅助因子相互作用，调控众多靶基因的表达，在机体的生长发育、新陈代谢、细胞分化及体内许多生理过程中发挥重要作用。为了探讨激素相关核受体及其辅助激活因子与骨质疏松之间的关系，通过检索有关激素核受体、核受体辅助因子的功能与骨质疏松的相关文献并进行综述，阐明了激素相关核受体(ER、AR、ERRα、PPARγ) 及其辅助激活因子(SRC-1、SRC-2)在骨骼发育中的重要作用，而核受体辅助激活因子SRC-3、PGC-1α 可能参与成骨细胞的增殖和分化过程，但作用机制尚不清楚。因此，深入研究SRC-3、PGC-1α 在骨代谢中的作用，将为我们深入了解骨质疏松的发病机制具有重要意义。
关键词：核受体；核受体辅助共激活因子；骨质疏松
Abstract: Abstract: Nuclear receptors (NRs) are members of a large family of ligand-activated transcription factors that act as transcriptional switches responding to lipophilic hormones， vitamins， dietary lipids， and other intracellular signals. A broad range of mRNA transcripts are regulated through interaction among NRs， their ligands， and their coactivators. NRs play important roles in virtually every aspect of mammalian physiology， including development， reproduction， metabolism， cell differentiation， etc. To investigate the relationship between hormone-related nuclear receptors， coactivators and osteoporosis， literatures of nuclear receptors and coactivators， and their important functions in osteoporosis were reviewed. The review illustrates that hormone-related NRs (ER， AR， ERRα， PPARγ) and their coactivators (SRC-1， SRC-2) play an important role in bone development. SRC-3 and PGC-1α have been shown to participate in osteoblast proliferation and differentiation， but their effects on bone metabolism in vivo and underlying mechanisms are still not clearly understood. Therefore， it is important that studying the roles of SRC-3 and PGC-1α in development of osteoporosis will help us further understand the pathogenesis of osteoporosis.
Key words: nuclear receptors; coactivators; osteoporosis
