《生命科学》 2013, 25(7): 654-660

Lkb1维持造血干细胞稳态及其机制研究进展

李程程，孟爱民^*

(中国医学科学院放射医学研究所，天津市核医学重点实验室，天津 300192)

摘　要：摘　要：造血干细胞(haematopoietic stem cells， HSCs) 具有自我更新功能，可分化成多系血细胞。微环境、活性氧(reactive oxidative species， ROS)、细胞周期调控分子和能量代谢等对HSCs 的稳态具有调节作用。抑癌基因Lkb1，又名STK11 (serine threonine protein kinase 11)，在多种细胞内磷酸化激活蛋白激酶AMPK(AMP-activated protein kinase)，调节机体代谢和细胞增殖。近期研究发现，Lkb1 在HSCs 的代谢调控及稳态维持中发挥重要作用。对Lkb1 在HSCs 数量、功能、代谢的稳态维持中的作用研究进展进行综述。
    关键词：造血干细胞；Lkb1 ；稳态；腺苷酸活化蛋白激酶

Lkb1 regulates the homeostasis of hematopoietic stem cell and the progress of its mechanism research

LI Cheng-Cheng， MENG Ai-Min^*

(Tianjin Key Laboratory of Molecular Nuclear Medicine， Institute of Radiation Medicine， Chinese Academy of Medical Sciences & Peking Union Medical College， Tianjin 300192， China)

Abstract: Abstract: Haematopoietic stem cells (HSCs) has the potentiality to renew themselves and to differentiate into specialized blood cells. The niche， ROS， cell cycle regulatory factor， and energy metabolism do influence the homeostasis of HSCs. Lkb1 promotes the phosphorylation of AMPK， regulating the organism metabolism and cell growth. The recent research discovered that Lkb1 has important role in the regulation of metabolism and maintaining homeostasis of HSCs. This article reviewed the research progress about the role of Lkb1 in the quantity， function， and metabolism homeostasis of HSCs.
    Key words: haematopoietic stem cell; Lkb1; homeostasis; AMPK