《生命科学》 2013, 25(6): 566-573

白藜芦醇神经保护作用的研究进展

王礼鹏^1，2，高召兵^1*

(1 中国科学院上海药物研究所受体结构重点实验室，上海 201203 ；2 南昌大学药学院，南昌 330006)

摘　要：摘　要：白藜芦醇属于多酚类化合物，是葡萄酒中的主要活性成分之一。白藜芦醇在脑缺血、脊髓损伤、癫痫以及神经退行性疾病等中具有广泛的生物活性，其神经保护机制可能包括抗氧化、抗炎、抑制兴奋性损伤、调控非编码小RNA (microRNA) 的表达以及相关信号通路的转导等。就自藜芦醇在神经系统中的生物活性予以综述。
关键词：白藜芦醇；抗氧化；生物活性；神经退行性疾病

Recent advances in the study on neuroprotection effects of resveratrol

WANG Li-Peng^1，2， GAO Zhao-Bing^1*

(1 Key Laboratory of Receptor Structure， Shanghai Institute of Materia Medica， Chinese Academy of Sciences， Shanghai 201203， China; 2 College of Pharmacy， Nanchang University， Nanchang 330006， China)

Abstract: Abstract: Resveratrol， a naturally occurring polyphenolic compound， is one major active component in red wine. Increasing evidence shows resveratrol has a wide range of bioactivities in the prevention and treatment of neuronal pathologies including brain ischemia， spine cord injury and neurodegenerative diseases. Effects of resveratrol include anti-oxidation， anti-inflammation， down-regulation of neuronal excitability， regulation of microRNA expression and signal pathway transduction. Here， we provide a review of recent advances on resveratrol， primarily focusing on the biological activity of resveratrol in neuronal pathologies.
Key words: resveratrol; anti-oxidation; biological activity; neurodegeneration