《生命科学》 2013, 25(5): 484-489

miR-128与恶性肿瘤关系的研究进展

李墨林¹，沃璐璐²，付红勇¹，方　龙¹，李传刚³，舒晓宏^4*

(1 大连医科大学病理生理学教研室，大连 116044； 2 大连医科大学2010级医疗系，大连 116044；3 大连医科大学附属二院泌尿外科，大连 116023；4 大连医科大学药学院，大连 116044)

摘　要：
摘　要：微小RNA (microRNA， miRNA)是一类长度为19~25个核苷酸、细胞内源性表达的单链非编码RNA，其通过转录后抑制或mRNA降解调控靶基因的表达，进一步调控靶蛋白参与的信号通路。微小RNA-128(miR-128)是一种在神经系统中高表达的miRNA，在神经系统的发育及正常生理功能的维持中发挥重要作用，其异常表达与神经胶质瘤、阿尔茨海默病等疾病密切相关。近年研究证实，miR-128与多种肿瘤细胞的增殖、分化、凋亡、侵袭和转移有关。miR-128已成为与肿瘤诊断、治疗和预后相关的具有潜在价值的肿瘤标志物，并有望成为肿瘤治疗的新靶点。就miR-128与恶性肿瘤关系的研究进展进行综述。
关键词：miR-128；恶性肿瘤；靶基因

Research progress on the relationship between miR-128 and malignant tumors

LI Mo-Lin¹， WO Lu-Lu²， FU Hong-Yong¹， FANG Long¹， LI Chuan-Gang³， SHU Xiao-Hong^4*

(1 Department of Pathophysiology， Dalian Medical University， Dalian 116044， China; 2 Department of Medicine， Dalian Medical University， Dalian 116044， China; 3 Division of Urology， Department of Surgery， the Second Affiliated Hospital of Dalian Medical University， Dalian 116023， China; 4 College of Pharmacy， Dalian Medical University， Dalian 116044， China)

Abstract: Abstract: MicroRNAs (miRNAs) are a class of small endogenous non-coding single chain RNAs containing 19~25 nucleotides， which regulate the expression of target genes through post-translational repression or mRNA degradation， thus further modulating its related signal transduction networks. MicroRNA-128 (miR-128) is a kind of brain-enriched miRNA， and plays important roles in the development of the nervous system and the maintenance of its normal physiological functions. It was reported that the aberrant expression of miR-128 is closely associated with glioma， Alzheimer’s disease， etc. Recent studies demonstrated that miR-128 is involved in proliferation， differentiation， apoptosis， invasion and metastasis of various tumor cells. miR-128 may serve as potential biomarkers for cancer diagnosis， treatment and prognosis， and is expected to become a new target for tumor therapy. In this review， we will focus on the relationship between miR-128 and malignant tumors.
Key words:  miR-128; malignant tumors; target genes