《生命科学》 2013, 25(5): 478-483

ZEB1在肺癌上皮-间质转化中作用的研究进展

冯　芸， 唐旭东^*

(广东医学院生物化学与分子生物学研究所，湛江 524023)

摘　要：摘　要：上皮-间质转化(epithelial-to-mesenchymal transition， EMT)是肿瘤侵袭和转移的首要步骤。ZEB1是EMT的关键转录因子之一，在肺癌EMT发生中起重要作用。ZEB1受LKB1等抑癌基因突变、miRNAs (如miR-200、miR-34a)水平、炎症或低氧肿瘤微环境等肺癌细胞内外因素的影响，主要通过抑制E-cadherin表达，引起肺癌细胞表型间质化。此外，ZEB1诱导肺癌EMT可能与TGF-β、COX-2等信号转导途径有关。
关键词：E盒结合锌指蛋白；肺癌；上皮-间质转化

Research progress of ZEB1 in epithelial-to-mesenchymal transition of lung cancer

FENG Yun ， TANG Xu-Dong^*

(Institute of Biochemistry and Molecular Biology， Guangdong Medical College， Zhanjiang 524023， China)

Abstract: Abstract: Epithelial-to-mesenchymal transition (EMT) is the initial step of tumor invasion and metastasis. ZEB1， a crucial transcription factor of EMT， plays a crucial role in the EMT of lung cancer. ZEB1， affected by multiple endogenous and exogenous factors， such as anti-oncogene mutation， inflammatory and hypoxic tumor environment and miRNAs (miR-200， miR-34a) level， inhibits E-cadherin expression， leading to the induction of mesenchymal phenotype in lung cancer cells. Moreover， TGF-β and COX-2 signaling pathways may be involved in EMT of lung cancer induced by ZEB1.
Key words: ZEB1; lung cancer; epithelial-to-mesenchymal transition