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《生命科学》 2013, 25(4): 402-409

脱氧雪腐镰刀菌烯醇对肠道结构与免疫功能的影响及机理
段杰林1，尹　杰2，3，吴苗苗2，3，陈明洪4，肖　昊2，3，何邵平1，李颖慧2，3，王　磊1，黄兴国1，张　彬1，李铁军2*
(1 湖南农业大学动物科学技术学院，长沙 410128；2 中国科学院亚热带农业生态研究所，中国科学院亚热带农业生态过程重点实验室，湖南省畜禽健康养殖工程技术中心，农业部中南动物营养与饲料科学观测实验站，长沙 410125；3 中国科学院研究生院，北京 100049；4 湖南农业大学生命科学技术学院，长沙 410128)

摘　要：摘　要：脱氧雪腐镰刀菌烯醇(deoxynivalenol， DON) 是谷物及谷物产品中最常见的一种真菌毒素，其主要通过激活丝裂原活化蛋白激酶(mitogen-activated protein kinases， MAPKs) 等细胞信号转导通路以及线粒体介导细胞凋亡途径而发挥免疫毒性作用—— 抑制蛋白质合成、诱导细胞凋亡、损伤肠道和抑制机体免疫等，对人和动物的健康造成了巨大的影响。综述了DON 对机体肠道的组织形态、屏障功能的损伤，及其对肠道相关细胞、黏膜免疫球蛋白的分泌、细胞因子的表达和肠道微生物平衡的影响，并进一步阐述了其作用机理，以期为DON 的研究提供参考。
关键词：脱氧雪腐镰刀菌烯醇；肠道；损伤；免疫功能；作用机理

Effects of deoxynivalenol on intestinal structure and immune functions and its underlying mechanisms of action
DUAN Jie-Lin1， YIN Jie2，3， WU Miao-Miao2，3， CHEN Ming-Hong4， XIAO Hao2，3， HE Shao-Ping1， LI Ying-Hui2，3， WANG Lei1， HUANG Xing-Guo1， ZHANG Bin1
(1 College of Animal Science and Technology， Hunan Agricultural University， Changsha 410128， China; 2 Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South-Central， Ministry of Agriculture， Hunan Provincial Engineering Research Center of Healthy Livestock， Key Laboratory of Agro-ecological Processes in Subtropical Region， Institute of Subtropical Agriculture， Chinese Academy of Sciences， Changsha 410125， China; 3 Graduate University of Chinese Academy of Science， Beijing 100049， China; 4 College of Bioscience and Biotechnology， Hunan Agricultural University， Changsha 410128， China)

Abstract: Abstract: Deoxynivalenol (DON) is one of the most common fungus mycotoxin in cereal grains and cereal products. It plays a significant role in inhibiting protein synthesis， inducing cells apoptosis and deteriorating intestinal tract through activating mitogen-activated protein kinases (MAPKs) or mitochondria-mediated cell apoptosis pathways， resulting in serious impairment of the health of animals and human beings. In this article， the effects of DON on the intestinal histological morphology and intestinal barrier functions， intestinal cells， immunoglobulin secretion and cytokine expression， the balance of intestinal microbial， as well as its underlying mechanism of action， were reviewed.
Key words: deoxynivalenol; intestine; impairment; immune function; mechanism of action

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