《生命科学》 2013, 25(4): 396-401

维甲酸诱导基因I的新功能

崔会会，邱春红，鲁秀敏^*

(重庆理工大学药学与生物工程学院，重庆 400054)

摘　要：摘　要：维甲酸诱导基因I (retinoic acid inducible gene-I， RIG-I) 最广为人知的生物学功能是抗病毒作用，其抗病毒作用机理及信号通路受到广泛关注。最近研究表明，RIG-I 不仅具有抗病毒功能，还参与炎症反应、细胞增殖分化、吞噬或细胞凋亡、免疫调节等诸多生物学事件。对RIG-I 在抗病毒固有免疫及其他领域功能的最新研究发现作一综述。
关键词：维甲酸诱导基因I ；抗病毒；炎症；细胞增殖

Noncanonical function of retinoic acid inducible gene-I

CUI Hui-Hui， QIU Chun-Hong， LU Xiu-Min^*

(College of Pharmacy and Biological Engineering， Chongqing University of Technology， Chongqing 400054， China)

Abstract: Abstract: The antiviral role of retinoic acid inducible gene-I (RIG-I) has been well recognized， and most studies focus on its activation mechanism and down-stream signaling pathway in antiviral response. Recently， accumulating evidence suggests that RIG-I not only functions in antiviral systems but also participates in a series of biological events， such as inflammation， cell proliferation， differentiation， apoptosis and even immunoregulation. Here we review recent advances in antiviral study of RIG-I as well as its functions in other fields.
Key words: retinoic acid inducible gene-I (RIG-I); antiviral signaling; inflammation; cell proliferation