《生命科学》 2013, 25(4): 365-371

胸苷激酶的研究进展

刘　程，郭果为，叶忠锋，黄晓红^*

(福建师范大学生命科学学院，福建省发育与神经生物学重点实验室，福州 350108)

摘　要：摘　要： 胸苷激酶(thymidine kinase， TK) 是嘧啶核苷酸补救合成途径的重要酶之一，包括两个亚家族：1 型TK 及2 型TK。这两种TK 的作用机理相同，都可以将脱氧胸苷磷酸化为脱氧胸苷一磷酸，但两者的蛋白结构及催化底物范围有较大差异。两种TK 都与人类及动物的各种疾病，如心肌病、肿瘤等密切相关，它们还影响寄生虫的毒性、生长及繁殖等。
关键词：胸苷激酶；脱氧胸苷；肿瘤；寄生虫

Research progress of thymidine kinase

LIU Cheng， GUO Guo-Wei， YE Zhong-Feng， HUANG Xiao-Hong^*

(Fujian Key Laboratory of Developmental Biology and Neuroscience， College of Life Science， Fujian Normal University， Fuzhou 350108， China)

Abstract: Abstract: Thymidine kinase is one of important enzymes involved in the DNA-salvage pathway， including type 1 and type 2 subfamilies. Both the two kinds of TK can phosphorylate deoxythymidine to deoxythymidine monophosphate through the same mechanism. However， the protein structure and catalytic substrates of them are different. Research has shown that both the two kinds of TK are associated with human and animal diseases， such as cardiomyopathy， tumor， etc. In addition， TK is also involved in the toxicity， growth and reproduction of parasites.
Key words: thymidine kinase; deoxythymidine; tumor; parasite