《生命科学》 2013, 25(4): 352-357

去泛素化酶CYLD

魏俊成^1，2，3，贺福初^1，2，3，王　建^1，2，3*

(1 中国医学科学院基础医学研究所，北京协和医学院基础学院，北京 100005；2 军事医学科学院放射与辐射医学研究所，北京蛋白质组研究中心，蛋白质组学国家重点实验室，北京102206；3 蛋白质药物国家工程研究中心，北京 102206)

摘　要：摘　要：肿瘤抑制因子CYLD (Cylindromatosis，头帕肿瘤综合征蛋白) 是一种去泛素化酶，cyld 基因突变或者缺失导致圆柱瘤，并与多种肿瘤的发生、发展密切关联。CYLD 通过自身去泛素化酶活性移除特定底物的K63 连接的泛素链，并负调控包括NF-κB 在内的多条信号通路。在生理条件下，通过磷酸化修饰和泛素化修饰，CYLD 的蛋白表达量和活性受到严格的调控。CYLD 与多种细胞学功能相关，如细胞运动和迁移、免疫和炎症反应、破骨细胞的形成等。
关键词：泛素化；去泛素化酶；CYLD ；炎症

CYLD: a deubiquitinase

WEI Jun-Cheng^1，2，3， HE Fu-Chu^1，2，3， WANG Jian^1，2，3*

(1 Institute of Basic Medical Sciences， Chinese Academy of Medical Science and Peking Union Medical College， Beijing 100005， China; 2 State Key Laboratory of Proteomics， Beijing Proteome Research Center， Beijing Institute of Radiation
    Medicine， Beijing 102206， China; 3 National Engineering Research Center for Protein Drugs， Beijing 102206， China)

Abstract: Abstract: The tumor suppressor CYLD (Cylindromatosis) is a deubiquitinase. Mutation or deletion in cyld gene induces cylindromatosis. This gene also has been associated with several types of carcinoma. It has been shown that CYLD negatively regulates different signaling pathways including NF-κB and JNK pathway by removing lysine 63-linked polyubiquitin chains from several specific substrates. CYLD is regulated by different mechanisms， such as phosphorylation and ubiquitination. CYLD participates in various cellular processes， ranging from immune
responses and inflammation to cell cycle control and osteoclastogenesis.
Key words: ubiquitination; deubiquitinase; CYLD; inflammation