《生命科学》 2013, 25(3): 334-341

蛋白质组学技术在中药复杂体系研究中的应用

赵　霞^1#，岳庆喜^2*，谢正兰^1#，李　铁¹，黄国坚¹，李井泉²，王　慧^2*

(1 广西中医药大学附属桂林市中医医院，桂林 541004；2 中国科学院上海生命科学研究院营养科学研究所，上海 200031)

摘　要：摘　要：系统生物学在中药复杂体系研究中的合理性和可行性已经得到了国内外中药研究者的广泛认可。在后基因组的时代，蛋白质组学成为系统生物学研究的重要组成部分，近年来蛋白质组学在中药复杂体系研究中的应用也已经有了很多成功的实例。现结合所在的实验室近年来开展的应用蛋白质组学技术对一些中药复杂体系进行的研究工作和对蛋白质组学主要研究技术在中药复杂体系研究中的应用思路进行了综述和探讨。

The application of proteomics in the research of traditional Chinese medicine complex system

ZHAO Xia^1#， YUE Qing-Xi^2*， XIE Zheng-Lan^1#， LI Tie¹， HUANG Guo-Jian¹， LI Jing-Quan²， WANG Hui^2*

(1 Guilin TCM Hospital of China， Guangxi University of Chinese Medicine， Guilin 541004， China; 2 Institute for Nutritional Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: The feasibility and rationality of systems biology on the research of traditional Chinese medicine complex system have been well accepted by Chinese herb researchers in the world. In post-genomic era， proteomics is the most important part of systems biology. Recently there are some successful cases of using proteomic techniques in traditional Chinese medicinal research. In this review， based on the recent years’ research work， the authors documented and discussed the possible application ideas of the main techniques of proteomics in the research of traditional Chinese medicine complex system.