(南昌大学第二附属医院胃肠外科,南昌 330006)

摘 要:摘 要:HER-2 基因是一个编码人类表皮生长因子受体的基因。近年来发现,HER-2 在胃癌的发生发展过程中起着重要的作用,HER-2 基因扩增与胃癌的转移及预后密切相关。现就对胃癌中HER-2 的检测方法、HER-2 与胃癌转移及预后的关系及主要的信号转导通路、抗HER-2 的单克隆药物应用等作一综述。

Roles of HER-2 in gastric cancer
SHU Wen-Bin, CAO Jia-Qing*
(Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, China)

Abstract: Abstract: HER-2 is a gene encoding human epidermal growth factor receptor. Recent studies show that the HER-2 gene plays a very important role in the development and progression of gastric cancer. In addition, there is a close relation between HER-2 overexpression and the metastasis and prognosis of gastric cancer. This article provides a review on the detection of HER-2 in gastric cancer, the relationship between HER-2 overexpression and gastric cancer metastasis and prognosis and the main involved signal transduction pathways, and the clinical application of anti-HER-2 monoclonal antibody.

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