《生命科学》 2013, 25(3): 311-314
摘 要：摘 要：硒蛋白P (selenoprotein P， SelP) 对于硒转运及维持硒水平稳定非常重要。硒蛋白P 主要分布于小脑、嗅球、海马区和额叶皮质，神经元和星形胶质细胞中均有其表达，对神经细胞具有保护作用，在维持正常的脑功能中发挥着重要作用。硒蛋白P 基因敲除导致小鼠神经损伤，甚至死亡。硒蛋白P 与阿尔茨海默症、帕金森综合征、癫痫等神经退行性疾病的发生有关。重点介绍硒蛋白P 在神经退行性变化方面的作用。
Abstract: Abstract: Selenoprotein P plays an important role in the transportation and homeostasis of selenium (Se). It is mainly distributed in the cerebellum， olfactory bulb， hippocampus and frontal cortex. The expression of selenoprotein P is observed in both neurons and astrocytes. Selenopotein P can protect nerves and is also importantfor maintaining the normal function of brain. The genetic deletion of selenoprotein P in mice can result in neurological dysfunction and even death. Selenoprotein P is also involved in neurodegeneration diseases including Alzheimer{$39}s disease， Parkinson{$39}s disease， and seizures. This paper focuses on the role of selenoprotein P in neurodegenerative changes.
