《生命科学》 2013, 25(3): 285-288

通过胞啃机制获得HLA-G对免疫细胞功能的影响

徐丹萍，林爱芬，颜卫华^*

(温州医学院附属浙江省台州医院中心实验室，临海 317000)

摘　要：摘　要：人类白细胞抗原-G (human leukocyte antigen G， HLA-G) 属于非经典HLA I 类分子，是机体内重要的免疫耐受分子。正常生理条件下，HLA-G 表达具有组织局限性。功能研究显示，HLA-G 与表达在免疫细胞表面的受体结合直接发挥免疫抑制功能，或通过诱导产生调节性T 细胞(regulatory T cells， Treg)，或通过胞啃(trogocytosis) 机制产生HLA-Gpos 免疫细胞间接参与机体的免疫耐受。就HLA-G 胞啃机制及其功能作一综述。

The effects of HLA-G acquisition on immune cells through trogocytosis

XU Dan-Ping， LIN Ai-Fen， YAN Wei-Hua^*

(Laboratory Center， Wenzhou Medical College Affiliated Taizhou Hospital of Zhejiang Province， Linhai 317000， China)

Abstract: Abstract: Human leukocyte antigen-G (HLA-G)， a non-classical HLA class I molecule， is an import antimmunotolerant factor. HLA-G expression is highly tissue-restricted in physiological conditions. HLA-G can directly inhibit the activation of a variety of immune cells by binding to receptors， or indirectly inhibit the immune response by inducing regulatory T cells or by producing HLA-Gpos immune cells through trogocytosis. In the present review， we discussed current findings on the HLA-G acquisition through trogocytosis and its function.