《生命科学》 2013, 25(2): 206-217

低氧与肿瘤

孙　恒，李雪冰，方　靖^*

(中国科学院上海生命科学研究院营养科学研究所，上海 200031)

摘　要：摘　要： 肿瘤细胞的快速生长使得肿瘤内部缺氧，导致低氧诱导因子HIF-α 的积累。HIF-α 可以引起多种基因的转录，使得肿瘤细胞能够耐受低氧环境。综述了肿瘤细胞感受和传导低氧信号的机制，并从肿瘤细胞增殖、凋亡、代谢、迁移、浸润、血管生成以及炎症和药物耐受等多方面论述了HIF-α 在肿瘤发生发展中所发挥的重要作用。以HIF-α 为靶点是治疗肿瘤的重要手段和方法。
关键词：低氧；低氧诱导因子；肿瘤

Hypoxia and tumors

SUN Heng， LI Xue-Bing， FANG Jing^*

(Institute for Nutritional Sciences， Shanghai Institutes for Biological Sciences， Chinese Academy of Sciences， University of Chinese Academy of Sciences， Shanghai 200031， China)

Abstract: Abstract: Hypoxia occurs in solid tumors as a result of an inadequate supply of oxygen， due to rapid cell proliferation and inefficient vascular supply. Hypoxia induces expression of hypoxia-inducible factor α (HIF-α) that activates transcription of many genes， which may help tumors adapting to the environment of low oxygen. HIF-α plays a critical role in tumor cell proliferation， survival， metabolism， metastasis and angiogenesis. It is also related to inflammation and drug resistance. Therefore， HIF-α is becoming an important target for cancer therapy.
Key words: hypoxia; hypoxia-inducible factor; tumor