《生命科学》 2013, 25(1): 73-77

自噬在帕金森病发生发展中的作用

胡晓梅¹，郭　斌¹，马　莎²，白　洁^1*

(1 昆明理工大学医学院，昆明 650500；2 云南省第一人民医院神经内科，昆明 650032)

摘　要：摘　要：自噬(autophagy)是溶酶体对自身结构的吞噬降解，自噬作用主要是清除降解细胞内受损伤的细胞结构、衰老的细胞器，以及不再需要的生物大分子。自噬在大部分真核细胞中存在，是一个高度保守的防御和保护机制，在细胞应激反应中能够维持细胞生理平衡。在哺乳动物中，自噬参与抗原递呈、炎症以及神经保护作用。帕金森病(Parkinson’s disease， PD)是一种常见的神经退行性疾病，其发病机制复杂。自噬在帕金森病的发病机制中起重要的作用，综述了自噬与帕金森病的关系。
关键词：自噬；帕金森病；泛素C末端水解酶L1

The roles of autophagy in progress and development of Parkinson’s disease

HU Xiao-Mei¹， GUO Bin¹， MA Sha²， BAI Jie^1*

(1 Medical Faculty， Kunming University of Science and Technology， Kunming 650500， China; 2 Department of Neurology， First People’s Hospital of Yunnan Province， Kunming 650032， China)

Abstract: Abstract: Autophagy is a process， in which cellular components are targeted to the lysosome for dissolving and degradation. It plays roles in eliminating damaged structures， aged organelles and intracellular un-required biomacromolecules. Autophagy is a high conserved defense and protective mechanism in eukaryotic cell. In response to stress， autophagy helps to maintain the cellular homeostasis. Autophagy is involved in various biological activities， such as antigen presentation， inflammation and neuroprotection. Parkinson’s disease (PD) is a common neurodegenerative disease， its pathogenesis is complicated. Autophagy plays an important role in the pathogenesis of PD. This paper reviews the relationship between autophagy and PD.
Key words: autophagy; Parkinson’s disease; ubiquitin carboxyl-terminal hydrolase L1