《生命科学》 2013, 25(1): 63-67

抑癌基因甲基化与宫颈癌的关系

符策岗，汪　磊，宋银宏^*

(三峡大学医学院，宜昌 443002)

摘　要：摘　要：肿瘤抑制基因启动子甲基化是表观遗传学改变的类型之一，与人类多种肿瘤相关。近年来的研究表明，P16INK4a、RASSF1A、APC、DAPK、E-cadherin、Syk、FHIT及FANCF等肿瘤抑制基因启动子甲基化导致其在宫颈肿瘤中表达下降，甚至缺失，这在宫颈癌发生、发展的过程中扮演着重要的角色。肿瘤抑制基因启动子甲基化为研究宫颈癌的发生机制、宫颈癌的筛查及治疗提供了新思路。就近年来对与宫颈肿瘤发生及发展密切相关的一些抑癌基因甲基化的研究做一简要综述。
关键词：宫颈癌；抑癌基因；甲基化

The relationship between methylation of tumor suppressor genes and cervical carcinogenesis

FU Ce-Gang， WANG Lei， SONG Yin-Hong^*

(Medical College， China Three Gorges University， Yichang 443002， China)

Abstract: Abstract: The promoters’ methylation of tumor suppressor genes (TSGs) is one kind of changes in epigenetics， which is concerned closely with multiple human tumors. Recent studies have shown that in cervical cancer tissues， the expression of TSGs such as P16INK4a， RASSF1A， APC， DAPK， E-cadherin， Syk， FHIT and FANCF is decreased or even absent， owing to their promoters’ methylation， which plays critical roles in cervical cancer carcinogenesis and progression. Furthermore， the phenomenon of TSGs’ methylation affords us a new idea to study the mechanism of the carcinogenesis as well as the screen and therapy of cervical cancer. This review summarized recent advances in the studies of the promoters’ methylation of some TSGs， which have a close relationship with cancer carcinogenesis and progression.
Key words: cervical cancer; tumor suppressor gene; methylation