《生命科学》 2013, 25(1): 58-62
摘 要：摘 要：动脉粥样硬化(atherosclerosis， AS) 是动脉系统的慢性炎症性疾病，免疫细胞和炎症介质对其发生、发展均有重要作用。高迁移率族蛋白1 (high mobility group box 1 protein， HMGB1)这一新发现的晚期炎症介质，具有促血管损伤后再狭窄和AS等多种病理生理效应。Treg细胞负向调节免疫应答，有效抑制机体炎症反应。AS患者Treg 细胞的数量减少或功能下降，提示Treg 细胞与AS病变相关。Toll样受体(Toll like receptors， TLRs)是诱导机体炎症反应重要的模式识别受体(pattern recogination receptors， PRRs)，现认为HMGB1是其家族中TLR2、4的内源性配体，而Treg细胞表达这两种受体。HMGB1与Treg细胞上的TLR2、4结合，可能直接影响其抑制作用，导致机体持续慢性炎症反应，参与AS的形成和发展。
关键词：高迁移率族蛋白1；Treg细胞；动脉粥样硬化；Toll样受体
Abstract: Abstract: Atherosclerosis (AS) is a chronic inflammatory autoimmune disease whose initiation and development could be affected by many immunial cells and inflammatory cytokine. At present， HMGB1 has been found to act as a late inflammtoy molecule that may damage endothelial cells， promote the proliferation of smooth muscle cells， and favor foam cell formation through various ways， which lead to the formation of lipid streaks and AS plaque. The regulatory T (Treg) cells can decrease inflammtory reaction and maintain immune tolerance effectively. Much evidence had showed the number or function of Treg cells decrease in patients of AS to imply some relation bewteen Treg cells’s changed and the incidence of AS. Toll like receptors (TLRs) are important pattern recognition receptors (PRRs)， which can promote immune inflammation. The combination of HMGB1 and TLR2 or TLR4 expressiong on the surface of Treg cells， will interfere the function and number of Treg cells directly and maintain or prolong body’s chornic inflammation which is the one most reason of AS. This paper briefly reviewed relative reports of the relationship among HMGB1， Treg cells and AS.
Key words: HMGB1; Treg cells; AS; TLR
