《生命科学》 2013, 25(1): 54-57

MicroRNAs与帕金森氏病

周小爽，李　晔，白　洁^*

(昆明理工大学医学院，昆明 650500)

摘　要：摘　要：帕金森氏病(Parkinson′s disease， PD)是中脑黑质多巴胺能神经元进行性减少的神经退行性疾病，其发病机制尚不清楚。目前研究表明，α-共核蛋白、Parkin等基因突变，以及环境毒素、线粒体损伤与帕金森氏病有关。MicroRNAs是小片段非编码RNA，通过转录后水平调节基因表达，在神经细胞分化、增殖、凋亡中起重要作用。综述了microRNAs与PD的相关性，并分析了microRNAs在PD病理生理过程中的作用。
关键词：帕金森氏病；microRNAs；α-共核蛋白

MicroRNAs and Parkinson′s disease

ZHOU Xiao-Shuang， LI Ye， BAI Jie^*

(Medical Faculty， Kunming University of Science and Technology， Kunming 650500， China)

Abstract: Abstract: The Parkinson′s disease (PD) is the neuronal degenerative disorder characterized by the progressive loss of dopaminergic neuron in substantia nigra of midbrain. The exact molecular mechanism is not yet clear. The studies showed that mutations of α-synuclein gene and Parkin gene， environmental toxins， as well as mitochondrial damage were related to PD. MicroRNAs are small non-coding RNAs that regulate gene expression through post-transcriptional regulation and play roles in the neuron differentiation， proliferation and apoptosis. The microRNAs with PD correlation， and analysis of the role of microRNAs in thepathophysiological process in PD were reviewed.
Key words: Parkinson′s disease; microRNAs; α-synaptic nucleoprotein