《生命科学》 2012, 24(8): 803-806

铁代谢紊乱与阿尔茨海默病

万　莉，赵保路^*

(中国科学院生物物理研究所，脑与认知国家重点实验室，北京 100101)

摘　要：
摘　要：很多研究表明脑内铁代谢紊乱与阿尔茨海默病有关，但其机理尚需深入探讨。综述这方面近年来的研究进展，特别是结合本实验室的研究结果，对铁代谢紊乱和氧化应激、β- 淀粉样蛋白和金属离子代谢紊乱、转铁蛋白和转铁蛋白受体、铁调节蛋白、二价金属离子转运体，及天然抗氧化剂通过调节金属代谢平衡缓解β- 淀粉样蛋白的毒性对细胞损伤的保护作用进行了深入讨论，旨在对今后这方面的研究及预防和治疗阿尔茨海默病有所帮助。
关键词：阿尔兹海默病；铁失衡；氧化应激；β- 淀粉样蛋白(Aβ) ；β- 淀粉样蛋白前体蛋白；铁调节蛋白；二价金属离子转运体；天然抗氧化剂
中图分类号：R589; R749.16 文献标志码：A

收稿日期：2012-04-19
基金项目：国家自然科学基金项目(30930036， 30870587)
*通信作者：E-mail: zhaobl@sun5.ibp.ac.cn; Tel: 010-64888569

Iron homeostasis disruption and Alzheimer’s disease

WAN Li， ZHAO Bao-Lu^*

(State Laboratory of Brain and Cognitive Science， Institute of Biophysics， Chinese Academy of Sciences， Beijing 100101， China)

Abstract:

Abstract: Many studies have shown there is a close relationship between iron homeostasis disruption and Alzheimer’s disease， but the mechanism needs to be discussed. Recent progresses about these studies are reviewed especially the results in author’s laboratory are discussed. Iron homeostasis disruption， oxidative stress， β-amyloid (Aβ)， amyloid precursor protein (APP)， iron regulatory protein (IRP) and divalent metal transporter 1(DMT1) are discussed in detail. The protective effects of natural antioxidant and mitochondrial ferritin (MtFt) against Alzheimer’s disease through regulating iron homeostasis disruption and oxidative stress are also discussed. This review may be useful for further research and prevention and therapy of Alzheimer’s disease.

    

Key words: Alzheimer’s disease; iron homeostasis disruption; oxidative stress; β-amyloid (Aβ); amyloid precursor protein (APP); iron regulatory protein (IRP); divalent metal transporter 1 (DMT1); natural antioxidant