《生命科学》 2012, 24(8): 731-741

脑铁代谢及调控

尤琳浩，郑　鑫，常彦忠^*

(河北师范大学生命科学学院 铁代谢分子生物学实验室，石家庄 050016)

摘　要：
    

摘　要：随着研究的深入，脑铁代谢相关分子突变引起的疾病越来越多的被人们所认识。脑铁代谢紊乱可能是神经退行性疾病的发病原因之一。对脑铁代谢机理的认识将为预防和治疗脑铁代谢紊乱相关疾病提供重要的理论根据。对脑铁代谢的过程，脑铁代谢的相关分子以及这些分子对脑内铁稳态的调控作用作一介绍。

    

关键词：脑铁代谢；血脑屏障；铁调素；IRP/IRe

    

中图分类号：Q614.81+1 ；Q493　　文献标志码：a


收稿日期：2012-04-05
基金项目：国家自然科学基金项目(10979025)；河北省杰出青年基金项目(C2010002032)
*通信作者：e-mail: chang7676@163.com

Brain iron metabolism and regulation

You Lin-hao， Zheng Xin， Chang Yan-Zhong^*

(Laboratory of Molecular Iron Metabolism， College of Life Science， Hebei Normal University， Shijiazhuang 050016， China)

Abstract:

Abstract: With further research， a growing number of diseases caused by mutations in the genes associated with brain iron metabolism has been recognized. Brain iron metabolism disorder may be one of causes of neurodegenerative diseases. Understanding of the mechanism of brain iron metabolism will provide important theoretical of prevention and treatment of brain iron metabolism disorder related diseases. In this paper， we introduce the process of brain iron metabolism， the molecules associated with brain iron metabolism and the regulation of brain ironhomeostasis.

    

Key words: brain iron metabolism; blood-brain barrier; hepcidin; IRP /IRE