BMP2基因在脂肪形成过程中的功能研究进展
何林芝,冷 丽*,李 辉*
(东北农业大学动物科学技术学院,农业部鸡遗传育种重点实验室,哈尔滨 150030)

摘 要:

摘 要:骨形态发生蛋白2 (BMP2)属于转化生长因子β (TGF-β)超家族成员,是一种分泌性蛋白,具有多重生物学功能。BMP2基因不仅可以诱导骨细胞的形成,还可以促进间充质干细胞向脂肪细胞分化,在脂肪的形成过程中发挥着重要作用。就该基因的结构、表达及其在诱导脂肪细胞形成方面的功能等进行综述。


    

关键词:BMP2基因;脂肪;结构;功能


    

中图分类号: Q786  文献标志码:A

Research progress of BMP2 gene function during fat formation
HE Lin-Zhi, LENG Li*, LI Hui*
(Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China)

Abstract:

 Abstract: Bone morphogenetic proteins (BMPs) belong to the transforming growth factor β (TGF-β) superfamily. It’s a kind of secretory protein with multiple biological functions. Researches indicates that BMP2 not only can induce the formation of bone cells, but also can promote emesenchymal stem cells to adipocytes, and plays a critical role in the formation of fat. This review summarized recent research progresses in gene structure, expression and function of BMP2.


    

Key words: BMP2 gene; fat; structure; function


    

 


    

收稿日期:2012-05-05; 修回日期:2012-06-18


    

基金项目:国家自然科学基金(31101708);教育部博士点新教师基金项目


    

*通信作者:E-mail: 冷丽, lengli1981@163.com; 李辉, lihui@neau.edu.cn

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